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Society and Animals Forum

Newsletter / Spring 1999
Volume 19

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PSYETA Head in Lab Animal Magazine:
Experiment Evaluation Method Should Spare Animals

PSYETA Executive Director Ken Shapiro, Ph.D., published in the November 1998 issue of Lab Animal magazine an article summarizing key points of a new evaluation method he and PSYETA recommend for animal models of human disorders. Shapiro's article, "Assessing Animal Models of Human Disorders: Validity vs. 'Productive Generativity,'" was the first part of "Looking at Animal Models: Both Sides of the Debate." The section also included "A Conversation with Ken Shapiro," which enabled Shapiro to explain further where his opponent's argument fell short.

Validation Not a Justification

 Shapiro's article explained that "validating" animal models as experimenters sometimes do- - showing similarities between animals they use and human beings- - does not demonstrate an experiment is of sufficient value to justify conducting or funding it. A scientific model is by definition analogous to the "original"- - sometimes the two have much in common, sometimes little. A valid model of a human disorder, highly similar to that which it models, may produce nothing of use for treating the disorder, while using a model dissimilar in major respects to that which it models may lead to breakthroughs. That is, validation fails to predict the value of an experiment.

Productive Generativity a Superior Standard

 A more useful standard than validation would ensure that fewer animals were used and that funding for psychological and biomedical research were more stringently applied. That is what Shapiro proposes: evaluation of a model's "productive generativity." 

Researchers should evaluate- - and Institutional Animal Care & Use Committees (IACUCs) should require them to evaluate- - past uses of a model: benefits to humans, citation frequency, clinicians' reliance on articles explaining the model, costs to animals experimented on, and other relevant factors.

To illustrate how such evaluations of animal models would work, Shapiro summarized his own in- depth study of animal models of human eating disorders. His detailed study showed no human benefit from use of those models, rare mention in later publications, and severe pain, distress, and harm to animals. The eating- disorders animal experiments were not based on close observation of eating disorders in humans; they borrowed from existing experimental procedures.

 In addition, the symptoms inflicted on animals differed from those of human eating disorders so as to make the studies inapplicable to human treatment, and in seeking pharmacological treatment, those studies   ignored the strong evidence that a "slimming culture" is a key contributing factor in the human disorders. Shapiro concluded,

I propose a reevaluation of research strategy. While models are only analogous to the subject under study, they ideally provide simplicity, accessibility, control, and ethical acceptability (avoiding the use of human subjects). The results of the present study suggest that these goals are not generally obtained. Some of us also believe that the ethical gain is in doubt, given philosophies that argue the moral consideration that non- human animals deserve.

 Limited payoff from some animal model research such as that presented above, combined with ethical concerns and the development of technologies that permit the noninvasive direct observation of disorders in living patients (e.g., positron emission tomography), may suggest alternative strategies to the development of animal models.

Vivisection Defended

 The part of the debate defending vivisection was "Teaching the Public about Animal Models in Biomedical Research," by Mary Ellenberger, D.V.M., M.S., director of the Division of Laboratory Medicine at the Tufts- New England Medical Center. Her central point was that, if the public and health- care professionals were better informed about vivisection, the practice would be more widely accepted.

 Ellenberger named a few instances in which human health- care breakthroughs were preceded by animal experiments, but her examples did not prove that the breakthroughs would not have occurred without the animal experiments. Her examples also failed to demonstrate that the animal models were adequately evaluated or that obtaining results in humans similar to those in the animals was anything more than a fortunate coincidence.

Defense Is Flawed

 Health practitioners' ignorance of animal experimentation, which Ellenberger laments, may not be arbitrary and may not serve to obscure benefits Ellenberger claims derive from the experiments; these professionals may be choosing to spend their valuable time familiarizing themselves with the research that counts most for their work: that involving human beings. As Shapiro's study of eating- disorder research suggests, clinicians do not study animal experiments because it is unlikely they have found them to be relevant or helpful.
Large Industry Audience

 Lab Animal has about 10,000 subscribers, mostly in animal experimentation, IACUCs, and industries vivisection supports- - animal breeding, cage and restraint manufacturing, and others. Animal rights advocates learn rationalizations for animal abuse and exploitation from the first moment they understand words, but   those who gain from animal- based industries must either go out of their way to encounter animal rights arguments or come upon them by accident. They may find it easy to dismiss our views.

Appearing as it does in "their" publication, Shapiro's Lab Animal article offers them a special opportunity to reevaluate their practices on a scientific basis. It will also reach thousands of students, enabling them to see through the typical defenses of animal experimentation and to consider their career plans carefully.

Book Even Better

 Thorough explanations of the productive generativity evaluation method for research models, the eating- disorders example, how vivisection became such a large industry despite poor results, the lack of adequate laws and regulations affecting animal laboratories and weak enforcement, and other key aspects of animal experimentation are provided in Shapiro's book Animal Models of Human Psychology: Critique of Science, Ethics, and Policy (Hogrefe and Huber, 1998)- - see Special Resources and Gifts.

PSYETA Head in Lab Animal Magazine:
Experiment Evaluation Method Should Spare Animals  

PSYETA Executive Director Ken Shapiro, Ph.D., published in the November 1998 issue of Lab Animal magazine an article summarizing key points of a new evaluation method he and PSYETA recommend for animal models of human disorders. Shapiro's article, "Assessing Animal Models of Human Disorders: Validity vs. 'Productive Generativity,'" was the first part of "Looking at Animal Models: Both Sides of the Debate." The section also included "A Conversation with Ken Shapiro," which enabled Shapiro to explain further where his opponent's argument fell short.

Validation Not a Justification

 Shapiro's article explained that "validating" animal models as experimenters sometimes do- - showing similarities between animals they use and human beings- - does not demonstrate an experiment is of sufficient value to justify conducting or funding it. A scientific model is by definition analogous to the "original"- - sometimes the two have much in common, sometimes little. A valid model of a human disorder, highly similar to that which it models, may produce nothing of use for treating the disorder, while using a model dissimilar in major respects to that which it models may lead to breakthroughs. That is, validation fails to predict the value of an experiment.

Productive Generativity a Superior Standard

 A more useful standard than validation would ensure that fewer animals were used and that funding for psychological and biomedical research were more stringently applied. That is what Shapiro proposes: evaluation of a model's "productive generativity." 


Spring 1999 Volume 19
Who We Are
 

Ken Shapiro, Executive Director
Mary Lou Randour, Program Director
Susie Burt, Development Director
Fran Albrecht, Copy Editor
David Cantor, PSYETA News Editor
Kadd Stephens, Administrative and Technical Asst.
Jeanie Freeman, Webmaster

Members of the Board

Sudhir P. Amembal, President
Lorin Lindner, Ph.D., Vice-President
Emmanuel Bernstein, Ph.D., Cofounder
Susan Curtiss, Ph.D.
Lynne Dow, Ph.D.
Deborah H. Fouts, M.S.
Carole Rayburn, Ph.D.
F. Barbara Orlans, Ph.D.

Board of Advisors

Roger S. Fouts, Ph.D.
Jane Goodall, Ph.D.
Birute Galdikas, Ph.D.
Peter Singer, D.Phil.


Federal Acceptance of Non-Animal Tests Is Focus of Bill

By Sara Amundson 

In a coalition termed "strange bedfellows" by Lab Animal magazine, animal advocates and the regulated industry are supporting establishment of a government committee to evaluate alternatives to toxicity tests using animals. Soon to be introduced in the 106th Congress, the ICCVAM Authorization Act would establish the Inter- Agency Coordinating Committee for the Validation of Alternative Methods (ICCVAM) as a permanent standing committee.  

 Stagnation a Serious Problem

Federal agencies' reluctance to accept alternatives to animal tests has frustrated animal advocates and caused manufacturers of promising methods to bankrupt their businesses. Some scientists also believe this failure on the part of the government has prevented the science of toxicology from progressing beyond decades- old technology.

"Think about it: We are about to begin the 21st century using many toxicology methods that were originally developed in the 1940s," says Kathy Stitzel, D.V.M., associate director of Corporate Professional Regulatory Services at The Procter & Gamble Company. "I can think of few other fields where acceptance of scientific progress has been so effectively blocked." 

Committee To Date: Small Step Forward

In the National Institutes of Health Revitalization Act of 1993, Congress directed the National Institute of Environmental Health Sciences (NIEHS) to "develop and validate assays and protocols, including alternative methods that can reduce or eliminate the use of animals in acute or chronic safety testing," to "establish criteria for the validation and regulatory acceptance of alternative testing," and to "recommend a process through which scientifically validated alternative methods can be accepted for regulatory use."

This mandate resulted in the establishment of ICCVAM. ICCVAM reviews non- animal methods for assessing risk and makes recommendations to federal agencies regarding those testing methods. It can update methods by recommending those that are more humane than animal tests and are equally or more predictive of toxicity in humans.

Officials of 14 federal regulatory and research agencies and programs comprise ICCVAM. Along with stakeholders, including animal advocacy organizations, in 1997 they produced the booklet Validation and Regulatory Acceptance of Toxicological Test Methods: A Report of the Ad Hoc ICCVAM.

Big Step Needed

However, a wealth of basic information on federal agencies' toxicology policies is still not available in a single document. The bill would require federal agencies to forward to ICCVAM all regulations, requirements and recommendations that encourage or require animal testing. ICCVAM would keep the information in a central repository. This is crucial for animal protectionists seeking exact federal regulations or requirements for animal testing and for companies researching and developing new methods that do not use animals. 

"Strange Bedfellows" Agree

The broad coalition backing the Act includes the American Humane Association, Colgate- Palmolive Company, Doris Day Animal League, The Gillette Company, The Humane Society of the United States, Massachusetts Society for the Prevention of Cruelty to Animals, and The Procter & Gamble Company. All desire quicker acceptance of alternatives to animal tests.

"While the Doris Day Animal League certainly does not support the continuing use of animals in product testing, time and again industry has related to us its frustration in gaining acceptance of alternative methods by the federal government," says Holly Hazard, executive director of the Doris Day Animal League. "This bill will facilitate acceptance, saving untold animal lives."

What You Can Do

Please ask your representative and senators to support and co- sponsor the ICCVAM Authorization Act. For more information, contact Sara Amundson at the Doris Day Animal League: 202- 546- 1761.

Sara Amundson is deputy director and legislative director of the Doris Day Animal League, where she has been employed for 10 years. She lobbied the Department of Transportation to accept the first alternative method for its hazardous transport packaging regulations. She chairs the Coalition for Consumer Information on Cosmetics and serves on the international committee of 50 animal organizations working to end the use of animals in cosmetics and household product testing.


Making  Strides

Grateful for Grant

PSYETA is pleased and grateful to announce that it has received a $5,000.00 grant from the Doris Day Animal League (DDAL) to assist in development of the animal abuser treatment program described in previous issues of PSYETA News. DDAL informed PSYETA of its decision in December 1998.

The grant will enable PSYETA to develop a training manual for counselors working with animal abusers. Recognition by mental health professionals that animal abuse is violent and dangerous behavior and a sign of serious emotional problems requiring treatment is one of PSYETA's highest priorities.

That is why PSYETA is establishing, along with the American Society for Prevention of Cruelty to Animals, New York City's first program to train mental health professionals in the treatment of animal abusers; worked to ensure passage of California's new law mandating psychological counseling for anyone convicted of animal abuse; and created Beyond Violence: The Human- Animal Connection, PSYETA's new video explaining the importance of human treatment of animals for animals' well-being and that of humanity.

 Says PSYETA Executive Director Ken Shapiro, "This support from DDAL means a great deal to PSYETA and its members. Through it we will be able to develop a training manual. It will help us spread the word far more quickly than we otherwise would have been able to. We are deeply thankful to DDAL."

Human- Animal Connection Recognized in China

The People's Republic of China, a nation with a dismal human rights record, has begun to recognize animals' civilizing effects.

 The South China Morning Post reported, on September 14, 1998, that the Dr. Dog patient therapy program, operating in Hong Kong since 1991, had been launched on China's mainland.

Four dogs certified for patient therapy sessions visited with 20 handicapped children on September 13th, according to the report. The plan is for animals and children to meet once a month at the Panyu Bear Sanctuary, about 12 miles south of Guangzhou.

 While there is always a danger that such programs might possibly become neglectful of some of the animals' needs, their effectiveness reflects the special bond between humans and other animals and the betrayal of the human- animal relationship inherent in using animals for experimentation, classroom dissection, hunting, fishing, bullfights and other bloodsports, and the many other abuses to which people subject animals.

PSYETA considers rectifying such injustices a top priority of a healthy society. Urging this task upon parents, educators, social workers, and others involved in shaping the character of the next generation is a key aim of the new PSYETA video, Beyond Violence: The Human- Animal Connection, mentioned above (also see page 11).

Student C.O. Established in Australian U.

 PSYETA has for years provided information to students and educators about non- animal teaching methods available to replace classroom uses of animals- - experiments using live animals and dissection of dead ones. Scientific studies of several fields of science and health care show that students taught with "alternative" methods are at least as competent as those taught with animals.

 As explained in- - you guessed it: Beyond Violence: The Human- Animal Connection! (see page 11)- - teaching young people that animals are learning tools violates the human- animal relationship that in a healthy society would be mutually beneficial, not exploitative.

 Several states now require that teachers provide alternatives for students who object on ethical grounds to dissection or other uses of animals. Many professional schools have conscientious objection policies. Yet concerted efforts are often necessary to obtain alternatives where requirements do not yet exist. Students face lowering of grades, intimidation by instructors, administrators who defer to instructors' "academic freedom," and other obstacles, so they often contact PSYETA and other organizations for assistance.

 We were delighted to hear from Australia veterinary student Andrew Knight. "On November 11, 1998, Perth's Murdoch University took the groundbreaking step of formally allowing conscientious objection by students to animal experimentation or other areas of their coursework," begins a report Knight e- mailed to us recently. "Murdoch is, to my knowledge, the first Australian university to formally take this step ...."

 Knight found himself "brought up hard against reality" in his first year of veterinary training, when students were required to dissect many animals and he "tried not to think too much about where all these bodies had come from."

Requesting alternatives and initially being refused, Knight persisted. He spoke repeatedly with instructors, obtained literature from animal organizations, and read Vivisection and Dissection in the Classroom: A Guide to Conscientious Objection, by Gary Francione and Anna Charlton of the Rutgers University Animal Rights Law Clinic. A fellow student joined him in his fight. He had to take legal action before his veterinary school would relent and let those who would provide health care to animals learn their profession in the most humane possible way. Knight prevailed, on the grounds that he had been discriminated against based on his religious beliefs. The school's new policy and the determined effort to establish it received widespread news coverage in Australia. Knight and many letter writers congratulated the University.
 


Historic Ruling: Court Grants Standing
in Primate Well-Being Case

By Valerie Stanley

On September 1, 1998, the eleven-member U.S. Court of Appeals for the District of Columbia Circuit issued a ground-breaking decision in the case brought by the Animal Legal Defense Fund (ALDF) and several individuals.

The case challenges the primate psychological well-being regulation issued in 1991 under the Animal Welfare Act (AWA) by the United States Department of Agriculture (USDA). The Court held that an individual who viewed primates in a zoo in conditions that did not promote the primates' psychological well-being had "standing"--i.e., could challenge in court USDA's regulation governing the primate's housing.

This case marks the first time a court has granted standing under the AWA.

The Case

 A plaintiff saw primates exhibited in barren cages, isolated from other primates. Seven judges held that the plaintiff had standing to bring the case against USDA. Four judges disagreed. The lawsuit alleges that the regulation authorizes research facilities, zoos and dealers to keep primates in conditions that are psychologically harmful to those animals and that this violates the 1985 Amendments to the AWA.

The Amendments mandated that USDA set standards for "a physical environment adequate to promote the psychological well-being of primates."

USDA's current regulation provides that regulated entities should "address" and "consider" on paper certain aspects of primates' environment. Thus, zoos and others essentially make their own rules rather than adhere to a government-mandated standard.

On October 30, 1996, the late U.S. District Judge Charles Richey ruled that plaintiffs had standing and the regulation was illegal. The National Association for Biomedical Research (NABR) intervened and appealed, along with USDA, arguing that plaintiffs did not have standing and that the regulation was legal. A three-judge panel of the Court of Appeals initially held that plaintiffs did not have standing, but  the September 1, 1998, decision reversed that ruling.

The Court of Appeals has yet to rule on whether the regulation is legal.

Standing Is Crucial

To bring a case in federal court, one must have the requisite "standing." Standing is the plaintiff's ability to present a "case or controversy." Pursuant to Article III of the U.S. Constitution, federal courts may only hear cases in which a "case or controversy" is found to exist.

The "case or controversy" requirement encompasses three elements. First, the plaintiff must suffer an "injury in fact." This means that his or her injury must be concrete, not abstract or hypothetical. Second, this injury must be caused by the defendants' actions. Third, the injury must be one that can be redressed, or remedied, by the action the plaintiff asks the Court to take. Finally, the interest the plaintiff seeks to protect must be within the "zone of interests" that the statute under which the case is brought seeks to protect.

Zoogoer Meets Standing Requirement

 The Court of Appeals majority opinion found all four elements satisfied in ALDF's primate psychological well-being case. The Court explained that prior Supreme Court cases have held that people's aesthetic interests in viewing animals are entitled to protection--in other words, a violation of that interest suffices for injury in fact. The Court recognized that the plaintiff had an aesthetic interest in seeing exotic animals in a nurturing habitat and that this interest was injured when the plaintiff saw the animals in their actual living conditions.

The Court stated that its ruling on plaintiff's injury proceeded logically from earlier cases holding that persons could sue when government actions threaten to wipe out an animal species altogether. The Court held in this case that people could also challenge government action that "leaves some animals in a persistent state of suffering."

 On the second and third elements, the Court held that the regulation caused the plaintiff's injury because USDA inspectors had found the zoo plaintiff visited to be in compliance with the regulation on every inspection and that regulations including more stringent standards would alleviate his aesthetic injury in seeing primates in inhumane conditions. Finally, the Court found that the interest in seeing animals humanely treated clearly was contemplated by the AWA.

NABR Seeks Supreme Court Review

 The government has not asked the Supreme Court to review the case, but NABR has. NABR argues that the plaintiff's injuries are subjective, not verifiable, and, unless the Supreme Court reverses the appeals court, the floodgates of litigation will be open to persons attempting to impose their own value preferences on entities subject to the AWA.

 The Supreme Court is expected to decide this spring whether or not to review the case. Until that time, there will be no ruling on whether the regulation on primate psychological well-being is legal.

Want To Know More?

 For more information, contact the Animal Legal Defense Fund at aldf@wt.infi.net.
 


Coalition Opposes Primate Experimentation

About 50,000 other- than- human primates- - chimpanzees, rhesus macaques, common marmosets, cotton- topped tamarins, and many others- - are used in U.S. laboratories every year. Many experiments involving monkeys and apes are conducted by psychologists. In recent decades, incremental progress has been made toward ending laboratory confinement of and experimentation on our closest animal relatives and toward improving conditions for them to the extent that they are kept in laboratories.

The Coalition to End Primate Experimentation (CEPE) is organizing the 1999 Primate Freedom Tour to take place June 1 through September 4, 1999. A caravan of concerned people from all over the U.S. with a specially purchased Freedom Tour bus, the Tour will stop and hold teach- ins, protests, and other activities at each of the seven National Institutes of Health- funded and operated Regional Primate Research Centers (RPRCs).

The RPRCs are located in Seattle, Washington; Beaverton, Oregon; Davis, California; Covington, Louisiana; Atlanta, Georgia; Southborough, Massachusetts; and Madison, Wisconsin, home of psychologist Harry Harlow's notorious maternal- deprivation experiments on infant chimpanzees and some offshoots that unfortunately continue to this day. Each RPRC is affiliated with a large university, and each holds thousands of primates.

En route between RPRCs, the tour will make special stops at other facilities with primate laboratories, where educational and protest activities will also take place. CEPE, a loosely organized group of animal advocates and activists with a common desire for an end to experimentation on other- than- human primates (PSYETA among them), plans to ensure that the 1999 Primate Freedom Tour informs as many people as possible of the injustice and unacceptability of primate experimentation.

CEPE has created a unique and original item to raise funds for the Tour: Freedom Tags. Resembling military "dog tags" and made to be worn around the neck (also available in keychain form), each Freedom Tag provides the serial number, gender, species, date of birth, and RPRC of one primate. Each comes with a beautifully printed insert giving information on CEPE and the tags and addresses of the RPRCs in case Freedom Tag wearers would like to inquire as to the well- being of "their" primates. Freedom Tags sell for $10.

For a 1999 Primate Freedom Tour brochure (includes schedule), contact PSYETA. For a brochure and a Freedom Tag, to support the Tour financially, and/or for additional information:

CEPE
P.O. Box 34293
Washington, DC 20043;

 Toll- free (888) 391- 8948;
cepemail@yahoo.com; and http://www.enviroweb.org/cepe.
 


Update: Professor Continues Pursuing IACUC
By Carol D. Raupp, Ph.D
.

In the Fall 1998 issue of PSYETA News, Dr. Raupp recounted how she had sought to serve on the Institutional Animal Care and Use Committee (IAUCUC) of California State University at Bakersfield, where she is a member of the Psychology Department. Despite her expertise in human- animal studies and other ethical issues related to IACUC activities, she was repeatedly rebuffed while less qualified faculty members were appointed- - plainly due to her known opposition to animal experimentation. Following is the latest from Dr. Raupp on her efforts to ensure the best possible treatment of animals at her university.

Knowing that there would be at least one opening on the IACUC in January, I again submitted a memo and attachments highlighting my expertise. These were returned to me with a statement that there were no openings. After I requested clarification, it was established that there was indeed an opening. I resubmitted my materials. They were again returned to me, this time with a note thanking me for my interest.

I was never formally notified of a decision regarding the IACUC opening, but I learned that an anthropology professor was appointed--another novice with regard to the issues and practices involved in the use of other-than-human animals in research. Despite receiving no agenda or other IACUC documents, I am attending meetings as a visitor.

At the February 5, 1999, IACUC meeting, the committee reviewed drafts of documents associated with standard operating procedures, such as protocol submission forms, that should have been in place before the animal research facility opened. The committee then made its semi-annual inspection tour of the laboratory.

 About 20 rats had been kept in the laboratory, in shoebox-size cages, since the spring of 1998. Another half-dozen were being fed a medication--they were to be anesthetized, and at that point some of their muscle tissue would be removed and they would be killed.

 An aquarium for flathead minows used in another study was examined. Approximately half of the fish to be used in the study died in transit--a higher proportion than usual.

 Animal research has now been established at California State University at Bakersfield. Therefore, I will continue to attend IACUC meetings, and I will apply for the next "non-researchers" opening, which is expected to become available in a year or two.


Special Resource & Gifts

Songbirds return, flowers bloom, overcoats are closet- bound. Warm weather and the return of spring bring that familiar, vital surge of... intellectual curiosity and renewed commitment to animals' well- being! PSYETA's well- crafted, informative, attitude- changing advocacy and gift items are precisely what you and yours need to take part in the annual renewal of life!

PSYETA's new video Beyond Violence: The Human-Animal Connection takes the blinders off even when you thought they were permanent! "How we treat animals influences--and is indicative of--the ways in which we treat one another," begins this clear and compelling story of humanity's connection to other animals as we now understand it and what it means for the future--ours and the animals'. 13 minutes. $19.95 individuals, $29.95 organizations. Includes booklet with discussion guide and list of resources.
 

Ken Shapiro's cutting-edge book Animal Models of Human Psychology: Critique of Science, Ethics and Policy completely and in detail exposes fundamental flaws rendering psychology-related and other animal experiments useless for advancing human health care. It clearly explains Animal Welfare Act regulations and other sometimes-mystifying aspects of experimentation. A must-read for psychologists and everyone else concerned with the important, urgent, and controversial problem of animal laboratories. 328 pages, hardcover. Hogrefe & Huber, 1998. Members $30.00, nonmembers $39.50.
 

Society & Animals: Social Scientific Studies of the Human Experience of Other Animals, a quarterly journal edited by Ken Shapiro, provides articles, commentaries and book reviews. Topics: research, education, medicine, and agriculture using animals; entertainment, companion animals, animal symbolism, and other popular-culture uses of animals; wildlife and the environment; and sociopolitical movements, public policy, and the law. Members $30.00 for three issues, nonmembers $40.00.
 

The Journal of Applied Animal Welfare Science (JAAWS), coedited by Ken Shapiro, makes available book reviews and articles on effects of captivity on naturally free-roaming animals; ways of minimizing pain and stress in animals in laboratories; methods for improving lives of animals raised for food; and other critical information researched by scholars in a broad range of disciplines. Members $17.50 for four issues, nonmembers $35.00.


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